Protection from non-homologous end joining at telomere

Across TCGA cell cohorts, RNA activity of the Protection from non-homologous end joining at telomere pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSRNP2, NMT1, and MAFK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSRNP2 grouped by Protection from non-homologous end joining at telomere-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CSRNP2 →	+0.707	+0.287	.004	.003	3	4
KIDNEY	NMT1 →	+0.651	+0.341	.009	.009	3	4
UPPER_AERODIGESTIVE_TRACT	MAFK →	+1.064	+0.233	.001	<.001	3	4
LUNG_NSCLC_LUSC	FBXO24 →	+0.350	+0.216	.003	<.001	3	3
LUNG_NSCLC_LUSC	UST →	-1.643	-0.238	<.001	<.001	3	3
LUNG_NSCLC_LUSC	PILRB →	+1.433	+0.283	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSRNP2 by Protection from non-homologous end joining at telomere activity — KIDNEY

Explore this box plot interactively →