Protection from non-homologous end joining at telomere

Across TCGA cell cohorts, RNA activity of the Protection from non-homologous end joining at telomere pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAM, PFKM, and CAPN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protection from non-homologous end joining at telomere activity versus PAM in BLOOD_Lymphoma (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PAM →	-2.608	-1.061	<.001	<.001	3	6
BLOOD_Leukemia	PFKM →	+1.595	+0.765	<.001	<.001	3	6
BLOOD_Lymphoma	CAPN2 →	-3.437	-1.068	<.001	<.001	3	6
BLOOD_Leukemia	YEATS4 →	+0.549	+0.847	<.001	<.001	3	6
BLOOD_Lymphoma	PLA2G4A →	-1.919	-1.109	.001	<.001	3	5
BLOOD_Lymphoma	GBP3 →	-1.178	-1.365	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031848 vs PAM — BLOOD_Lymphoma

Explore this scatter interactively →