Negative regulation of lipopolysaccharide-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipopolysaccharide-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL16, ZAP70, and RCSD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipopolysaccharide-mediated signaling pathway activity versus IL16 in GBM (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL16 →	+0.487	+0.071	<.001	<.001	3	8
LSCC	ZAP70 →	+0.769	+0.064	<.001	<.001	3	6
LSCC	RCSD1 →	+0.657	+0.068	<.001	<.001	3	6
LSCC	SEPTIN1 →	+0.474	+0.044	<.001	<.001	3	6
BRCA	SEPTIN1_S206 →	+0.707	+0.051	.002	.001	3	6
LSCC	SH2D1A →	+0.843	+0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031665 vs IL16 — GBM

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