Negative regulation of lipopolysaccharide-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipopolysaccharide-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B2M, LINC01814, and LINC02605, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipopolysaccharide-mediated signaling pathway activity versus B2M in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	B2M →	+0.436	+0.480	.004	.004	3	4
CCRCC	LINC01814 →	-0.404	-0.461	.008	.003	3	4
UCEC	LINC02605 →	+1.000	+0.291	.001	<.001	3	3
UCEC	SIX2 →	-0.896	-0.309	<.001	<.001	3	3
LUAD	GBP2 →	+0.535	+0.634	.002	.002	2	4
LUAD	PTPN22 →	+0.604	+0.719	.002	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031665 vs B2M — LSCC

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