Negative regulation of lipopolysaccharide-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipopolysaccharide-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS4, SHLD2, and AP3M2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipopolysaccharide-mediated signaling pathway activity versus THBS4 in BLOOD_Leukemia (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	THBS4 →	+2.235	+0.852	<.001	.009	3	4
LARGE_INTESTINE	SHLD2 →	-0.678	-0.930	.004	.008	2	4
BLOOD_Lymphoma	AP3M2 →	-1.475	-2.012	.006	<.001	3	3
LUNG_NSCLC_LUAD	ANXA5 →	+1.075	+0.338	.001	<.001	3	3
SOFT_TISSUE	SEPTIN3 →	+3.356	+1.768	<.001	<.001	3	3
SOFT_TISSUE	SLC17A7 →	+1.975	+1.989	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031665 vs THBS4 — BLOOD_Leukemia

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