Positive regulation of heat generation

Across TCGA cell cohorts, RNA activity of the Positive regulation of heat generation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICAL1, SMN1, and RAC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MICAL1 grouped by Positive regulation of heat generation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MICAL1 →	-1.477	-1.050	<.001	.002	3	5
LUNG_NSCLC_LUSC	SMN1 →	+0.725	+0.318	.001	.009	3	3
PANCREAS	RAC1 →	-0.516	-0.893	.003	.006	3	3
PANCREAS	LMAN1L →	+0.043	+0.851	.002	.009	3	3
OESOPHAGUS	USP14 →	+1.176	+0.274	.004	.007	3	3
OESOPHAGUS	ANKRD33B →	+1.886	+0.269	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MICAL1 by Positive regulation of heat generation activity — SKIN

Explore this box plot interactively →