Regulation of heat generation

Across TCGA patient cohorts, RNA activity of the Regulation of heat generation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD34, HSP90AA1, and RRP36_S73, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heat generation activity versus CD34 in BRCA (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD34 →	+0.569	+0.046	.002	.001	3	7
LSCC	HSP90AA1 →	-0.360	-0.072	<.001	<.001	3	7
LSCC	RRP36_S73 →	-0.784	-0.072	<.001	<.001	3	6
LSCC	TRIM33_S862 →	-0.624	-0.078	<.001	<.001	3	6
BRCA	TNS2_S120 →	+0.423	+0.052	.004	<.001	3	6
PDAC	COL16A1 →	+0.460	+0.059	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031650 vs CD34 — BRCA

Explore this scatter interactively →