Regulation of heat generation

Across TCGA patient cohorts, RNA activity of the Regulation of heat generation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGES, ENPP7P10, and SLC38A5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heat generation activity versus PTGES in CCRCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTGES →	+1.739	+0.336	<.001	<.001	3	5
LSCC	ENPP7P10 →	-0.527	-0.180	.009	.005	3	5
BRCA	SLC38A5 →	+0.510	+0.098	.006	.005	3	5
LSCC	DSN1 →	-0.573	-0.187	.001	<.001	3	4
LSCC	CNKSR2 →	-0.489	-0.192	.001	.004	3	4
LSCC	GKAP1 →	-0.675	-0.191	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031650 vs PTGES — CCRCC

Explore this scatter interactively →