Regulation of heat generation

Across TCGA cell cohorts, RNA activity of the Regulation of heat generation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPT2-EGFL8, MAPKAPK5, and CHCHD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPT2-EGFL8 grouped by Regulation of heat generation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPT2-EGFL8 →	-0.205	-1.528	.003	<.001	3	4
LUNG_NSCLC_LUAD	MAPKAPK5 →	-0.166	-0.721	.005	<.001	3	4
SOFT_TISSUE	CHCHD2 →	-0.292	-2.309	.006	<.001	3	3
SOFT_TISSUE	INCA1 →	-0.324	-1.365	<.001	.003	3	3
BLOOD_Leukemia	MTRR →	-0.147	-1.010	.001	.001	3	3
BLOOD_Leukemia	OS9 →	-0.233	-1.348	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPT2-EGFL8 by Regulation of heat generation activity — BLOOD_Leukemia

Explore this box plot interactively →