Regulation of heat generation

Across TCGA cell cohorts, RNA activity of the Regulation of heat generation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGES, NMU, and DCLK2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heat generation activity versus PTGES in URINARY_TRACT (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PTGES →	+3.767	+0.985	<.001	.001	3	12
PANCREAS	NMU →	+3.351	+1.015	<.001	<.001	3	10
URINARY_TRACT	DCLK2 →	-1.499	-0.910	<.001	.002	3	8
OVARY	ZNF775 →	-0.842	-0.842	<.001	.001	3	8
LUNG_NSCLC_LUSC	SLC6A16 →	-0.844	-1.483	.003	.002	3	7
BREAST	AVPI1 →	+0.988	+0.909	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031650 vs PTGES — URINARY_TRACT

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