Regulation of heat generation

Across TCGA cell cohorts, RNA activity of the Regulation of heat generation pathway is significantly associated with the drug response of multiple features, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Rucaparib, GSK-LSD1-2HCl, and PD173074, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Rucaparib grouped by Regulation of heat generation-low versus -high activity in OESOPHAGUS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Rucaparib →	-0.264	-1.518	.003	.025	3	2
OESOPHAGUS	GSK-LSD1-2HCl →	-0.339	-1.665	.026	.008	3	2
UPPER_AERODIGESTIVE_TRACT	PD173074 →	-0.639	-1.498	.038	.021	3	1
UPPER_AERODIGESTIVE_TRACT	BAY-MPS1 →	-0.749	-0.855	.019	.032	3	1
UPPER_AERODIGESTIVE_TRACT	LGK974 →	-0.419	-1.057	.010	.038	3	1
UPPER_AERODIGESTIVE_TRACT	SGC0946 →	-0.517	-0.308	<.001	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Rucaparib by Regulation of heat generation activity — OESOPHAGUS

Explore this box plot interactively →