Protein destabilization

Across TCGA patient cohorts, RNA activity of the Protein destabilization pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCN, TRPC1, and TEX48, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein destabilization activity versus DCN in PDAC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DCN →	-0.494	-0.271	.009	.003	3	3
BRCA	TRPC1 →	-0.576	-0.224	.002	.003	3	3
PDAC	TEX48 →	+0.236	+0.279	<.001	.001	3	3
GBM	PHF19 →	+0.473	+0.176	.004	<.001	3	3
GBM	GYPC →	-0.639	-0.146	.001	.001	3	3
GBM	MCTP2 →	-0.658	-0.140	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031648 vs DCN — PDAC

Explore this scatter interactively →