Protein destabilization

Across TCGA cell cohorts, RNA activity of the Protein destabilization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTL8C, TBC1D9, and DCAF13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein destabilization activity versus RTL8C in LUNG_SCLC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RTL8C →	+0.863	+0.228	.004	.002	3	4
LARGE_INTESTINE	TBC1D9 →	+1.206	+0.974	<.001	<.001	3	4
BLOOD_Leukemia	DCAF13 →	+0.430	+0.480	.008	.007	3	4
OESOPHAGUS	HS6ST2 →	-2.988	-1.147	<.001	.003	3	3
OESOPHAGUS	TCOF1 →	-0.804	-0.805	<.001	.005	3	3
LUNG_SCLC	AAMDC →	+1.072	+0.261	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031648 vs RTL8C — LUNG_SCLC

Explore this scatter interactively →