Positive regulation of nervous system process

Across TCGA patient cohorts, RNA activity of the Positive regulation of nervous system process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3G, HEATR1, and RPL5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nervous system process activity versus EIF3G in GBM (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EIF3G →	-0.168	-0.113	<.001	<.001	3	7
GBM	HEATR1 →	-0.210	-0.066	<.001	<.001	3	7
OV	RPL5 →	-0.190	-0.047	<.001	.006	3	6
OV	RPS5 →	-0.333	-0.069	<.001	<.001	3	6
GBM	RPL11 →	-0.187	-0.073	<.001	<.001	3	6
CCRCC	TPPP →	+0.796	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031646 vs EIF3G — GBM

Explore this scatter interactively →