Negative regulation of nervous system process

Across TCGA patient cohorts, RNA activity of the Negative regulation of nervous system process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO19, AAAS, and GRIA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nervous system process activity versus MYO19 in LUAD (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYO19 →	-0.378	-0.540	.002	.003	3	4
PDAC	AAAS →	-0.260	-0.576	<.001	.001	3	3
HNSC	GRIA3 →	-0.545	-0.442	.004	.003	3	3
PDAC	RPL23AP74 →	+0.190	+0.415	.004	.001	2	4
LUAD	LINC01060 →	-0.257	-0.589	.006	<.001	3	3
PDAC	SUOX →	-0.317	-0.520	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031645 vs MYO19 — LUAD

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