Negative regulation of nervous system process

Across TCGA cell cohorts, RNA activity of the Negative regulation of nervous system process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM2, VPS51, and EGF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nervous system process activity versus TPM2 in PANCREAS (Pearson r = -0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TPM2 →	-4.549	-2.069	.002	<.001	3	4
PANCREAS	VPS51 →	+0.603	+2.069	.003	<.001	3	3
BREAST	EGF →	+3.572	+1.826	<.001	<.001	3	3
OVARY	BTNL9 →	-2.305	-2.134	.007	.003	3	3
LUNG_SCLC	ARRDC2 →	+2.145	+1.881	.009	<.001	3	3
LUNG_SCLC	PDLIM3 →	+2.994	+2.042	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031645 vs TPM2 — PANCREAS

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