Regulation of nervous system process

Across TCGA patient cohorts, RNA activity of the Regulation of nervous system process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECSCR, SHROOM4, and FHL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nervous system process activity versus ECSCR in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ECSCR →	+0.253	+0.475	.004	.002	3	5
UCEC	SHROOM4 →	+0.358	+0.419	.005	.001	3	5
LSCC	FHL5 →	+0.516	+0.493	.001	.001	3	4
UCEC	F10 →	+0.545	+0.349	.002	.006	3	4
LSCC	NPR1 →	+0.772	+0.608	<.001	.007	3	4
LSCC	KCNK3 →	+0.894	+0.861	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031644 vs ECSCR — LSCC

Explore this scatter interactively →