Positive regulation of myelination

Across TCGA cell cohorts, RNA activity of the Positive regulation of myelination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QKI, CD22, and SYDE1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myelination activity versus QKI in LUNG_SCLC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	QKI →	+1.988	+0.143	<.001	<.001	3	9
BLOOD_Lymphoma	CD22 →	-2.240	-0.070	.008	.009	3	6
PANCREAS	SYDE1 →	+1.608	+0.126	<.001	.001	3	6
SOFT_TISSUE	ENAH →	+1.085	+0.146	.001	<.001	3	6
CNS	KCTD3 →	+0.447	+0.112	<.001	<.001	3	6
LUNG_NSCLC_LUAD	ITSN1 →	+0.815	+0.133	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031643 vs QKI — LUNG_SCLC

Explore this scatter interactively →