Positive regulation of myelination

Across TCGA cell cohorts, RNA activity of the Positive regulation of myelination pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R11, PHEX, and TP53, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R11 grouped by Positive regulation of myelination-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP1R11 →	+0.265	+1.169	.002	.003	3	3
BREAST	PHEX →	+0.146	+0.652	.001	.007	3	3
BREAST	TP53 →	+0.341	+0.907	<.001	.001	3	3
BREAST	HBB →	+0.135	+0.627	.003	.009	3	3
LUNG_NSCLC_LUSC	LRIT3 →	-0.180	-0.323	.007	.009	3	3
LUNG_NSCLC_LUSC	KLHL20 →	+0.166	+0.389	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R11 by Positive regulation of myelination activity — BLOOD_Leukemia

Explore this box plot interactively →