Positive regulation of myelination

Across TCGA cell cohorts, RNA activity of the Positive regulation of myelination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC3B, ELL3, and SRM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myelination activity versus FNDC3B in BLOOD_Lymphoma (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FNDC3B →	+1.897	+0.730	.008	.007	3	4
OVARY	ELL3 →	-1.004	-0.493	.002	.007	3	4
BLOOD_Leukemia	SRM →	+0.521	+0.902	.001	.001	3	4
STOMACH	ATP10B →	-1.569	-0.772	.001	.003	3	3
BREAST	RAB11A →	-0.512	-0.778	<.001	.004	3	3
BREAST	MMP14 →	+2.709	+0.663	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031643 vs FNDC3B — BLOOD_Lymphoma

Explore this scatter interactively →