Negative regulation of myelination

Across TCGA cell cohorts, RNA activity of the Negative regulation of myelination pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2AK3, FIG4, and CTSC, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2AK3 grouped by Negative regulation of myelination-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EIF2AK3 →	-0.253	-1.347	.002	<.001	3	10
LUNG_NSCLC_LUSC	FIG4 →	-0.288	-1.768	<.001	<.001	3	6
BLOOD_Leukemia	CTSC →	-0.455	-1.192	<.001	.003	3	6
LUNG_SCLC	JAM2 →	-0.238	-1.198	.001	.003	3	6
PANCREAS	DUSP12 →	-0.136	-1.024	.004	.001	2	6
KIDNEY	TNF →	-0.252	-1.502	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2AK3 by Negative regulation of myelination activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →