Negative regulation of myelination

Across TCGA cell cohorts, RNA activity of the Negative regulation of myelination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL6, MPLKIP, and ZCCHC18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, METTL6 grouped by Negative regulation of myelination-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	METTL6 →	-0.789	-1.011	.003	.001	3	4
OESOPHAGUS	MPLKIP →	+0.983	+0.333	<.001	.001	3	4
KIDNEY	ZCCHC18 →	-0.818	-1.220	.008	<.001	3	3
LUNG_NSCLC_LUSC	CDC42BPG →	+2.662	+1.493	<.001	<.001	3	3
OESOPHAGUS	H2BC21 →	+1.817	+0.338	<.001	<.001	3	3
KIDNEY	YTHDC1 →	+0.584	+1.274	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

METTL6 by Negative regulation of myelination activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →