Negative regulation of myelination

Across TCGA cell cohorts, RNA activity of the Negative regulation of myelination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP42, SLC9A3R1, and RBP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myelination activity versus USP42 in LUNG_SCLC (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	USP42 →	+0.443	+0.340	.001	.002	3	2
LUNG_SCLC	SLC9A3R1 →	-1.360	-0.340	.003	.002	3	2
LUNG_SCLC	RBP2 →	+0.120	+0.278	.006	.009	3	2
LUNG_SCLC	PLEKHB2 →	-0.603	-0.340	.006	.002	3	2
LUNG_SCLC	RO60 →	+1.114	+0.340	.004	.002	3	2
LUNG_SCLC	IPO5 →	-1.366	-0.467	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031642 vs USP42 — LUNG_SCLC

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