Plasminogen activation

Across TCGA cell cohorts, RNA activity of the Plasminogen activation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCHSD1, SLC12A5, and BEND6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FCHSD1 grouped by Plasminogen activation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FCHSD1 →	-0.735	-0.880	<.001	.004	3	3
LUNG_NSCLC_LUAD	SLC12A5 →	+1.142	+0.685	.002	.003	3	3
OVARY	BEND6 →	-0.927	-0.832	.001	<.001	3	3
BREAST	NYNRIN →	+1.160	+0.610	<.001	.005	3	3
LARGE_INTESTINE	GCSH →	+1.102	+1.201	<.001	.001	2	4
LARGE_INTESTINE	ZBTB7C →	-2.045	-1.352	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FCHSD1 by Plasminogen activation activity — SKIN

Explore this box plot interactively →