Zymogen activation

Across TCGA patient cohorts, RNA activity of the Zymogen activation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYD, AKAP1, and MNDA, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zymogen activation activity versus DPYD in GBM (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DPYD →	+1.045	+0.098	<.001	<.001	3	10
LSCC	AKAP1 →	-0.459	-0.053	<.001	<.001	3	9
GBM	MNDA →	+1.230	+0.117	<.001	<.001	3	9
OV	PLAU →	+0.886	+0.070	<.001	<.001	3	9
GBM	HNRNPU →	-0.242	-0.065	<.001	<.001	3	9
GBM	SKAP2 →	+0.801	+0.104	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031638 vs DPYD — GBM

Explore this scatter interactively →