Zymogen activation

Across TCGA patient cohorts, RNA activity of the Zymogen activation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA5, SLC2A3, and SERPINE1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zymogen activation activity versus ITGA5 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ITGA5 →	+1.193	+0.238	<.001	<.001	3	9
LUAD	SLC2A3 →	+1.191	+0.163	<.001	.002	3	8
GBM	SERPINE1 →	+1.342	+0.281	.001	<.001	3	8
HNSC	TREM1 →	+1.055	+0.229	<.001	<.001	3	8
OV	PPP1R18 →	+1.078	+0.261	.001	<.001	3	8
OV	ARHGAP9 →	+0.851	+0.262	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031638 vs ITGA5 — OV

Explore this scatter interactively →