Zymogen activation

Across TCGA cell cohorts, RNA activity of the Zymogen activation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSGIN1, HLA-DMA, and HSPD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OSGIN1 grouped by Zymogen activation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OSGIN1 →	-1.006	-0.640	.005	<.001	3	4
LIVER	HLA-DMA →	-1.914	-1.129	.001	.004	3	4
CNS	HSPD1 →	+0.508	+0.628	.002	.005	3	4
LARGE_INTESTINE	SIRT4 →	+0.700	+0.219	.004	.006	2	4
BREAST	GMPR2 →	-0.837	-0.918	<.001	<.001	3	3
BREAST	RABAC1 →	-0.863	-0.670	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OSGIN1 by Zymogen activation activity — BREAST

Explore this box plot interactively →