Zymogen activation

Across TCGA cell cohorts, RNA activity of the Zymogen activation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF771, SUSD1, and CDPF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zymogen activation activity versus ZNF771 in OVARY (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF771 →	+0.927	+0.359	.001	.002	3	6
BLOOD_Leukemia	SUSD1 →	-1.686	-0.292	<.001	<.001	3	5
BLOOD_Leukemia	CDPF1 →	+0.616	+0.172	.007	.009	3	5
SKIN	HBEGF →	-0.998	-0.228	.003	<.001	3	4
SKIN	ATP5F1A →	+0.561	+0.328	.007	<.001	3	4
SKIN	SAMD12 →	-1.254	-0.281	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031638 vs ZNF771 — OVARY

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