Receptor internalization

Across TCGA patient cohorts, RNA activity of the Receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD8, CLEC1A, and SCN7A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor internalization activity versus STARD8 in OV (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STARD8 →	+0.582	+0.166	<.001	.001	3	6
BRCA	CLEC1A →	+0.466	+0.173	.004	.004	3	6
LUAD	SCN7A →	+1.121	+0.100	<.001	<.001	3	6
HNSC	NCF4 →	+0.734	+0.116	.004	.004	3	5
LSCC	RASSF4 →	+0.626	+0.144	<.001	.002	3	5
HNSC	BIN2 →	+0.851	+0.148	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031623 vs STARD8 — OV

Explore this scatter interactively →