Receptor internalization

Across TCGA cell cohorts, RNA activity of the Receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC80, FAM214B, and PLIN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor internalization activity versus CCDC80 in LIVER (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CCDC80 →	+4.492	+0.364	.002	.006	3	7
LUNG_NSCLC_LUSC	FAM214B →	+1.952	+0.377	.007	.007	3	7
BREAST	PLIN3 →	+0.949	+0.231	<.001	.002	3	7
BREAST	EHD2 →	+3.599	+0.280	<.001	.004	3	7
CNS	HEG1 →	+1.338	+0.263	.007	.001	3	7
OESOPHAGUS	PSORS1C1 →	+1.480	+0.260	<.001	.006	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031623 vs CCDC80 — LIVER

Explore this scatter interactively →