Positive regulation of fever generation

Across TCGA patient cohorts, RNA activity of the Positive regulation of fever generation pathway is significantly associated with the RNA expression of multiple genes, with the LGG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1B, PTGS2, and TNF, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fever generation activity versus IL1B in LGG (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	IL1B →	+2.088	+0.094	<.001	<.001	3	27
UCEC	PTGS2 →	+1.600	+0.097	<.001	<.001	3	26
LGG	TNF →	+1.480	+0.082	<.001	<.001	3	25
ESCA	CXCL3 →	+1.707	+0.067	<.001	<.001	3	24
READ	CXCL8 →	+1.917	+0.056	<.001	<.001	3	24
GBM	GPR84 →	+1.084	+0.090	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031622 vs IL1B — LGG

Explore this scatter interactively →