Positive regulation of fever generation

Across TCGA patient cohorts, RNA activity of the Positive regulation of fever generation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KDM5A_S1331, PGLYRP1, and RETN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fever generation activity versus KDM5A_S1331 in PDAC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KDM5A_S1331 →	-1.060	-0.064	<.001	.001	3	8
GBM	PGLYRP1 →	+1.180	+0.152	<.001	<.001	3	8
GBM	RETN →	+1.162	+0.120	<.001	<.001	3	7
PDAC	SERPINB10 →	+0.978	+0.066	.001	<.001	3	7
UCEC	ELANE →	+0.660	+0.321	.005	.005	3	7
GBM	MMP9 →	+1.468	+0.134	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031622 vs KDM5A_S1331 — PDAC

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