Positive regulation of fever generation

Across TCGA cell cohorts, RNA activity of the Positive regulation of fever generation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALNT1, ASCL1, and FNBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B4GALNT1 grouped by Positive regulation of fever generation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	B4GALNT1 →	+2.625	+1.311	.001	.004	3	3
KIDNEY	ASCL1 →	+0.104	+1.155	.003	<.001	3	3
CNS	FNBP1 →	-0.676	-0.969	.002	.005	3	3
LUNG_SCLC	ELFN1 →	+2.432	+0.357	.009	.002	2	4
LARGE_INTESTINE	UBA3 →	+0.523	+0.991	.005	.003	3	3
LARGE_INTESTINE	RALA →	-0.603	-0.912	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B4GALNT1 by Positive regulation of fever generation activity — KIDNEY

Explore this box plot interactively →