Regulation of fever generation

Across TCGA patient cohorts, RNA activity of the Regulation of fever generation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMP9, KDM5A_S1331, and TOP2B_S1413, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fever generation activity versus MMP9 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP9 →	+1.397	+0.099	<.001	.002	3	7
OV	KDM5A_S1331 →	-0.606	-0.044	<.001	.001	3	7
LSCC	TOP2B_S1413 →	-0.559	-0.085	.003	.002	2	7
PDAC	H1-1 →	+0.925	+0.060	<.001	.002	3	6
GBM	RETN →	+1.086	+0.077	<.001	.009	3	6
LSCC	SNRNP200 →	-0.229	-0.078	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031620 vs MMP9 — GBM

Explore this scatter interactively →