Regulation of fever generation

Across TCGA cell cohorts, RNA activity of the Regulation of fever generation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPYSL3, BMP4, and B4GALNT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPYSL3 grouped by Regulation of fever generation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DPYSL3 →	-3.093	-1.781	.005	.001	3	4
KIDNEY	BMP4 →	-1.993	-0.895	<.001	.006	3	4
KIDNEY	B4GALNT1 →	+1.687	+1.217	.008	.004	3	4
LUNG_SCLC	FAM189B →	+0.821	+0.664	.001	.008	3	4
BREAST	ARNTL →	-0.907	-1.093	.002	<.001	3	4
SKIN	GMPR →	-3.136	-1.082	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPYSL3 by Regulation of fever generation activity — URINARY_TRACT

Explore this box plot interactively →