Hemidesmosome assembly

Across TCGA patient cohorts, RNA activity of the Hemidesmosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNFT2, ZNF620, and ITGB4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hemidesmosome assembly activity versus RNFT2 in UCEC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNFT2 →	-0.620	-0.779	<.001	.002	3	6
HNSC	ZNF620 →	-0.946	-0.519	<.001	.001	3	6
LSCC	ITGB4 →	+0.812	+0.939	.004	.004	3	5
LSCC	PLAU →	+1.018	+0.953	<.001	.002	3	5
LSCC	MPHOSPH9 →	-0.509	-1.217	<.001	<.001	3	5
GBM	CCDC150 →	-0.414	-0.704	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031581 vs RNFT2 — UCEC

Explore this scatter interactively →