Hemidesmosome assembly

Across TCGA cell cohorts, RNA activity of the Hemidesmosome assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF2, PSMB5, and NFKB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRSF2 grouped by Hemidesmosome assembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SRSF2 →	-0.655	-0.211	<.001	<.001	3	5
OVARY	PSMB5 →	-0.534	-0.244	<.001	.002	3	5
LUNG_SCLC	NFKB1 →	-0.221	-0.293	.001	.004	3	5
OESOPHAGUS	RNASE10 →	+0.265	+0.213	.001	<.001	3	5
LIVER	MRPL38 →	-0.517	-0.164	.007	.005	3	5
LUNG_NSCLC_LUAD	HNRNPM →	+0.254	+0.110	.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRSF2 by Hemidesmosome assembly activity — LARGE_INTESTINE

Explore this box plot interactively →