Membrane raft organization

Across TCGA cell cohorts, RNA activity of the Membrane raft organization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF862, GPS2, and RNPEPL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF862 grouped by Membrane raft organization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF862 →	+1.629	+1.359	<.001	<.001	3	5
STOMACH	GPS2 →	-0.953	-1.237	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	RNPEPL1 →	+0.923	+1.310	.001	.005	3	5
OVARY	WIPF3 →	+0.715	+0.770	.005	.005	3	4
BONE	CENPW →	-1.157	-1.628	.007	.001	3	4
SKIN	RPP30 →	-0.629	-1.267	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF862 by Membrane raft organization activity — BONE

Explore this box plot interactively →