Membrane raft organization

Across TCGA cell cohorts, RNA activity of the Membrane raft organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLITRK6, RAB15, and YY1AP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane raft organization activity versus SLITRK6 in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLITRK6 →	+2.429	+0.268	.001	<.001	3	6
BLOOD_Lymphoma	RAB15 →	+2.200	+0.270	.003	.007	3	5
LUNG_SCLC	YY1AP1 →	+0.756	+0.293	.003	.001	3	5
LUNG_SCLC	B3GNT9 →	+1.298	+0.286	.001	.002	3	5
LUNG_NSCLC_LUAD	TP53I13 →	+0.875	+0.149	<.001	.001	3	5
LUNG_NSCLC_LUAD	ZSCAN16 →	+1.043	+0.157	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031579 vs SLITRK6 — BREAST

Explore this scatter interactively →