Mitotic intra-S DNA damage checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic intra-S DNA damage checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRCC2, PABPC1L, and CEP152, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic intra-S DNA damage checkpoint signaling activity versus XRCC2 in DLBC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	XRCC2 →	+1.157	+0.052	<.001	<.001	3	33
UCS	PABPC1L →	+1.961	+0.056	<.001	<.001	3	32
SCLC	CEP152 →	+2.487	+0.104	<.001	<.001	3	32
THYM	CCDC18 →	+0.939	+0.058	<.001	<.001	3	32
THYM	DNA2 →	+1.265	+0.064	<.001	<.001	3	32
DLBC	ZGRF1 →	+0.845	+0.049	.001	.001	2	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031573 vs XRCC2 — DLBC

Explore this scatter interactively →