Mitotic intra-S DNA damage checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic intra-S DNA damage checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RECQL4, FANCG, and EHMT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic intra-S DNA damage checkpoint signaling activity versus RECQL4 in LSCC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RECQL4 →	+0.832	+0.913	<.001	<.001	3	7
HNSC	FANCG →	+0.463	+0.750	.002	.001	3	7
BRCA	EHMT2 →	+0.405	+0.409	.008	.006	3	7
LSCC	PATZ1 →	+0.584	+0.815	<.001	<.001	3	6
LSCC	TMEM97 →	+1.300	+0.928	<.001	<.001	3	6
LSCC	TIMELESS →	+0.671	+0.728	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031573 vs RECQL4 — LSCC

Explore this scatter interactively →