DNA integrity checkpoint signaling

Across TCGA cell cohorts, RNA activity of the DNA integrity checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPARG, ZW10, and CORO7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA integrity checkpoint signaling activity versus PPARG in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PPARG →	-2.782	-0.252	<.001	<.001	3	4
BONE	ZW10 →	+0.977	+0.368	.003	.004	3	4
LUNG_NSCLC_LUAD	CORO7 →	+0.492	+0.126	.006	.001	2	4
UPPER_AERODIGESTIVE_TRACT	ZBED9 →	-0.807	-0.188	<.001	.005	3	3
OESOPHAGUS	SGMS2 →	-1.145	-0.105	.005	.006	3	3
LARGE_INTESTINE	RPH3AL →	-1.342	-0.160	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031570 vs PPARG — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →