Regulation of termination of DNA-templated transcription

Across TCGA patient cohorts, RNA activity of the Regulation of termination of DNA-templated transcription pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2B, RIOK2_S337, and RCOR3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of termination of DNA-templated transcription activity versus TOP2B in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOP2B →	+0.295	+0.047	.009	.005	3	6
LUAD	RIOK2_S337 →	-0.528	-0.044	<.001	.009	3	6
HNSC	RCOR3 →	+0.310	+0.086	.004	.001	3	5
GBM	TRIM28 →	+0.303	+0.045	.006	.005	3	5
LSCC	VPS9D1_S116 →	-0.847	-0.061	<.001	<.001	3	5
LSCC	WDR5 →	+0.293	+0.052	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031554 vs TOP2B — LSCC

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