Regulation of termination of DNA-templated transcription

Across TCGA cell cohorts, RNA activity of the Regulation of termination of DNA-templated transcription pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK1, TSC22D2, and ZCCHC3, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNK1 grouped by Regulation of termination of DNA-templated transcription-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	WNK1 →	-0.738	-1.821	<.001	<.001	3	12
LUNG_NSCLC_LUAD	TSC22D2 →	-0.227	-1.031	<.001	<.001	3	5
KIDNEY	ZCCHC3 →	+0.345	+1.359	.004	.001	2	6
LUNG_SCLC	SCAF4 →	-0.361	-1.286	<.001	.005	3	5
STOMACH	RPS6KA4 →	+0.155	+0.314	.002	<.001	3	4
BLOOD_Myeloma	ABHD8 →	+0.100	+0.304	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNK1 by Regulation of termination of DNA-templated transcription activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →