Regulation of termination of DNA-templated transcription

Across TCGA cell cohorts, RNA activity of the Regulation of termination of DNA-templated transcription pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2A2, RINL, and ALG5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTF2A2 grouped by Regulation of termination of DNA-templated transcription-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GTF2A2 →	+0.554	+0.837	<.001	.004	3	4
LARGE_INTESTINE	RINL →	+0.891	+0.191	.006	.002	3	3
LUNG_NSCLC_LUAD	ALG5 →	+0.562	+0.359	.005	.006	3	3
LUNG_SCLC	NMRAL1 →	-1.339	-0.592	.006	.005	3	3
LUNG_NSCLC_LUAD	GAL3ST3 →	-0.071	-0.251	.008	.009	3	3
LIVER	FLAD1 →	+1.041	+0.368	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTF2A2 by Regulation of termination of DNA-templated transcription activity — OVARY

Explore this box plot interactively →