Regulation of termination of DNA-templated transcription

Across TCGA cell cohorts, RNA activity of the Regulation of termination of DNA-templated transcription pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRXN1, MBTD1, and STBD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of termination of DNA-templated transcription activity versus SRXN1 in BONE (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SRXN1 →	-2.707	-0.361	.007	.004	3	5
BONE	MBTD1 →	+0.859	+0.304	.006	.002	3	5
BONE	STBD1 →	-1.926	-0.367	.003	.004	3	5
BLOOD_Leukemia	ZNF585B →	+0.967	+0.387	<.001	.009	3	4
SOFT_TISSUE	ZNF253 →	+1.858	+1.489	.002	.001	3	4
SOFT_TISSUE	ZNF607 →	+1.328	+1.167	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031554 vs SRXN1 — BONE

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