Ruffle organization

Across TCGA patient cohorts, RNA activity of the Ruffle organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL16, SRPK1_S311, and YME1L1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ruffle organization activity versus IL16 in UCEC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL16 →	+0.488	+0.059	<.001	<.001	3	8
BRCA	SRPK1_S311 →	-0.767	-0.031	<.001	<.001	3	7
BRCA	YME1L1 →	-0.255	-0.030	<.001	<.001	3	7
COAD	CYGB →	+0.266	+0.032	.002	<.001	3	7
LSCC	ARHGEF6_S684 →	+0.603	+0.029	<.001	<.001	3	7
GBM	DOCK11 →	+0.382	+0.052	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031529 vs IL16 — UCEC

Explore this scatter interactively →