Ruffle organization

Across TCGA cell cohorts, RNA activity of the Ruffle organization pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A8, EPB41L4A, and SLCO4A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC7A8 grouped by Ruffle organization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC7A8 →	+0.163	+1.071	.001	.006	3	4
LIVER	EPB41L4A →	-0.320	-1.661	.001	<.001	3	3
BLOOD_Leukemia	SLCO4A1 →	+0.195	+0.858	.003	.006	3	3
BLOOD_Leukemia	RBMX →	-0.204	-0.723	.001	.003	3	3
SOFT_TISSUE	SFN →	+0.222	+0.967	.003	.009	3	3
OVARY	SERPINB12 →	-0.228	-0.948	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC7A8 by Ruffle organization activity — OESOPHAGUS

Explore this box plot interactively →