Ruffle organization

Across TCGA cell cohorts, RNA activity of the Ruffle organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM104B, TMEM265, and TTC7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM104B grouped by Ruffle organization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM104B →	-0.726	-1.413	.003	<.001	3	5
STOMACH	TMEM265 →	+3.155	+1.063	<.001	.005	2	5
BREAST	TTC7A →	+1.138	+0.824	<.001	<.001	3	4
BREAST	SPECC1 →	+1.242	+0.925	<.001	<.001	3	4
STOMACH	CAST →	+1.738	+1.389	<.001	<.001	3	4
BLOOD_Myeloma	SCN5A →	-0.156	-1.454	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM104B by Ruffle organization activity — LARGE_INTESTINE

Explore this box plot interactively →