Subtelomeric heterochromatin formation

Across TCGA patient cohorts, RNA activity of the Subtelomeric heterochromatin formation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC23IP, ZNF598, and RPL10A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Subtelomeric heterochromatin formation activity versus SEC23IP in GBM (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEC23IP →	-0.184	-0.033	.001	.005	3	5
COAD	ZNF598 →	-0.323	-0.039	.004	.004	3	5
OV	RPL10A →	-0.238	-0.040	.004	.008	3	5
GBM	KHSRP →	+0.274	+0.049	<.001	<.001	3	5
OV	RPL5 →	-0.129	-0.036	.002	.002	3	4
OV	RPL7A →	-0.319	-0.055	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031509 vs SEC23IP — GBM

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